While Riot was mocked for giving SlitherSlither, I thought it was interesting. What if all physiological traits were represented in its champion's abilities?
New Innate:Cassiopeia cannot purchase Boots and instead gains 9 Movement Speed per level, for a base movement speed of <span class="pp-tooltip" style="position:relative; border-bottom:1px dotted; cursor:help; color: Lua error: bad argument #1 to 'lc' (string expected, got nil).;" data-size="18" data-values="349☂358☂367☂376☂385☂394☂403☂412☂421☂430☂439☂448☂457☂466☂475☂484☂493☂502☂1☂2☂3☂4☂5☂6☂7☂8☂9☂10☂11☂12☂13☂14☂15☂16☂17☂18" data-label1="Level" data-values1="☂" >349 − 502 (based on level).
Lee Sin is blind, self-inflicted as penance for a fatal act of irresponsibility. Though unable to see, he has honed his hearing to more than offset the impairment.
Blind Monk
Revised Innate: Lee Sin reveals enemies within a 1300 radius whenever they are hit by a basic attack (any source) or ability, which lasts for 3.5 seconds.
Lissandra is blind, mauled by an ursine prior to gaining immortality. Through her ice, though, she sees the world.
Iceborn
Revised Innate: Lissandra coats a 550-radius area around her or her claw with Ice which lingers for 60 / 75 / 90 / 105 / 120 (based on level) seconds. Lissandra gains sight over her Ice, limited to those bits connected to her current position.